The hyperbaric oxygen preconditioning-induced brain protection is mediated by a reduction of early apoptosis after transient global cerebral ischemia.
Publication/Presentation Date
1-1-2008
Abstract
We hypothesized that the brain-protective effect of hyperbaric oxygen (HBO) preconditioning in a transient global cerebral ischemia rat model is mediated by the inhibition of early apoptosis. One hundred ten male Sprague-Dawley (SD) rats (300-350 g body weight) were allocated to the sham group and three other groups with 10 min of four-vessel occlusion, untreated or preconditioned with either 3 or 5 hyperbaric oxygenations. HBO preconditioning improved neurobehavioral scores and reduced mortality, decreased ischemic cell change, reduced the number of early apoptotic cells and hampered a conversion of early to late apoptotic alterations. HBO preconditioning reduced the immunoreactivity of phosphorylated p38 in vulnerable neurons and increased the expression of brain derived neurotrophic factor (BDNF) in early stage post-ischemia. However, preconditioning with 3 HBO treatments proved less beneficial than with 5 HBO treatments. We conclude that HBO preconditioning may be neuroprotective by reducing early apoptosis and inhibition of the conversion of early to late apoptosis, possibly through an increase in brain BDNF level and the suppression of p38 activation.
Volume
29
Issue
1
First Page
1
Last Page
13
ISSN
0969-9961
Published In/Presented At
Ostrowski, R. P., Graupner, G., Titova, E., Zhang, J., Chiu, J., Dach, N., Corleone, D., Tang, J., & Zhang, J. H. (2008). The hyperbaric oxygen preconditioning-induced brain protection is mediated by a reduction of early apoptosis after transient global cerebral ischemia. Neurobiology of disease, 29(1), 1–13. https://doi.org/10.1016/j.nbd.2007.07.020
Disciplines
Medicine and Health Sciences
PubMedID
17822911
Department(s)
Fellows and Residents
Document Type
Article