Chronic lymphocytic leukemia cell CD38 expression and inducible nitric oxide synthase expression are associated with serum IL-4 levels.
Publication/Presentation Date
1-1-2006
Abstract
B cell chronic lymphocytic leukemia (CLL) CD38 expression is variable and may predict outcome. Inducible nitric oxide synthase (NOS2) expression regulates CLL cell apoptosis. IL-4 and IFN-gamma regulate B cell CD38 expression and NOS2 expression. We compared IL-4 and IFN-gamma serum levels between CLL patients and normal individuals, and determined whether serum IL-4 and IFN-gamma levels correlated with CLL cell CD38 expression and NOS enzyme activity. IL-4 levels, but not IFN-gamma levels, differed between normal individuals and CLL patients. Furthermore, there was an association of IL-4 levels, but not IFN-gamma levels, with CD38 and NOS2 expression in CLL patients.
Volume
30
Issue
1
First Page
24
Last Page
28
ISSN
0145-2126
Published In/Presented At
Levesque, M. C., Chen, Y., Beasley, B. E., O'Loughlin, C. W., Gockerman, J. P., Moore, J. O., & Weinberg, J. B. (2006). Chronic lymphocytic leukemia cell CD38 expression and inducible nitric oxide synthase expression are associated with serum IL-4 levels. Leukemia research, 30(1), 24–28. https://doi.org/10.1016/j.leukres.2005.05.022
Disciplines
Medicine and Health Sciences
PubMedID
16039714
Department(s)
Fellows and Residents
Document Type
Article