Effect of selenium- and glutathione-enriched yeast supplementation on a combined atherosclerosis and diabetes hamster model.
Publication/Presentation Date
10-17-2007
Abstract
Selenium has a central role in antioxidant pathways as a cofactor to glutathione peroxidase. The present study evaluated the effects of four different preparations of inactivated yeast containing various concentrations of selenium and glutathione on a combined atherosclerosis and diabetes hamster model. The hamsters were supplemented with the yeast products for three months. The enriched yeast with the highest selenium and glutathione levels reduced the weight loss induced by diabetes, inhibited an increase in plasma cholesterol and triglyceride caused by a high-cholesterol and high-fat diet, increased the time taken for oxidation of lower density lipoproteins (lag time), and inhibited the formation of atherosclerosis better than low selenium/glutathione yeast supplementation. It was concluded that the yeast prepared to provide high selenium and high glutathione was the best for effecting beneficial changes in glutathione, cholesterol, atherosclerosis, and for demonstrating an antioxidant effect. The high selenium and low glutathione yeast was the best for improving selenium and glucose levels.
Volume
55
Issue
21
First Page
8731
Last Page
8736
ISSN
0021-8561
Published In/Presented At
Agbor, G. A., Vinson, J. A., Patel, S., Patel, K., Scarpati, J., Shiner, D., Wardrop, F., & Tompkins, T. A. (2007). Effect of selenium- and glutathione-enriched yeast supplementation on a combined atherosclerosis and diabetes hamster model. Journal of agricultural and food chemistry, 55(21), 8731–8736. https://doi.org/10.1021/jf0711901
Disciplines
Medicine and Health Sciences
PubMedID
17880156
Department(s)
Fellows and Residents
Document Type
Article