Use of methylene blue for treatment of severe sepsis in an immunosuppressed patient after liver transplantation.
Publication/Presentation Date
1-1-2013
Abstract
Sepsis in the immunosuppressed patient is associated with very high mortality and morbidity. Treatment of sepsis in immunocompromised patients is especially challenging due to an unbalanced systemic inflammatory reaction with subsequent development of profound vasoplegia. Methylene blue (MB) has been successfully used for the treatment of refractory hypotension, but its use has not previously been reported for treatment of sepsis in immunosuppressed patients. The mechanism of MB's action is thought to be due to its inhibitory effect on cGMP-mediated vasodilatation. This case report describes the successful use of MB for treatment of severe septic shock in an immunosuppressed patient after liver transplantation. Hypotension in this patient was refractory to volume repletion and a combination of vasopressors. After MB administration, hemodynamic stability was rapidly reestablished. In the setting of severe sepsis in an immunosuppressed patient, MB should be considered early as a therapeutic option for treatment of refractory vasoplegia.
Volume
2013
First Page
203791
Last Page
203791
ISSN
2090-6943
Published In/Presented At
Ramamoorthy, S., Patel, S., Bradburn, E., Kadry, Z., Uemura, T., K Janicki, P., Shah, R. A., & Bezinover, D. (2013). Use of methylene blue for treatment of severe sepsis in an immunosuppressed patient after liver transplantation. Case reports in transplantation, 2013, 203791. https://doi.org/10.1155/2013/203791
Disciplines
Medicine and Health Sciences
PubMedID
23762740
Department(s)
Fellows and Residents
Document Type
Article