Adrenal steroidogenesis in the spontaneously hypertensive rat (SHR).
Publication/Presentation Date
2-1-1975
Abstract
Adrenal vein catheterizations were done in SHR and control rats at different ages during the development of hypertension. All SHR became hypertensive by 15 weeks of age. The secretion rate of aldosterone was significantly reduced at 8 weeks of age, 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) at 12 weeks of age, deoxycorticosterone (DOC) at twenty weeks of age, and corticosterone (B) at 12 and 20 weeks of age. Secretion data suggest either an enzyme block, or increased conversion of known steroids to an unknown steroid product. Reduced secretion of corticosterone could explain the adrenal hyperplasia observed in SHR which may be important to the development of hypertension in these animals.
Volume
96
Issue
2
First Page
416
Last Page
420
ISSN
0013-7227
Published In/Presented At
Moll, D., Dale, S. L., & Melby, J. C. (1975). Adrenal steroidogenesis in the spontaneously hypertensive rat (SHR). Endocrinology, 96(2), 416–420. https://doi.org/10.1210/endo-96-2-416
Disciplines
Medicine and Health Sciences
PubMedID
1116474
Department(s)
Fellows and Residents
Document Type
Article