Safety and Efficacy of Protamine after Transcatheter Aortic Valve Replacement.
Publication/Presentation Date
9-23-2024
Abstract
Transfemoral Trans-catheter Aortic Valve Replacement (TF-TAVR) is a safe alternative to surgical aortic valve replacement (SAVR). Protamine is used to reverse heparin and reduce post-TAVR bleeding, but concerns about risks like valve thrombosis and stroke remain. This systematic review and meta-analysis, following PRISMA guidelines, found no statistically significant difference in major bleeding complications between the protamine and control groups [(3.0% vs. 14.4%); RR: 0.56; P=0.16]. No differences were noted in life-threatening bleeding, blood transfusions, 30-day mortality, or stroke. Protamine appears safe post-TAVR without increasing stroke risk, but its effectiveness in reducing bleeding needs further investigation through a multicentric randomized study.
ISSN
2213-3763
Published In/Presented At
Kumaraguruparan, L. D., Anandaram, A., Sambandam, K. G., Chidambaram, Y., Kidambi, B. R., Karthikeyan, G. G., Kasi, M., Abdulkader, R. S., Ramesh, S., Ramalingam, V., Rajendran, R., & Senguttuvan, N. B. (2024). Safety and Efficacy of Protamine after Transcatheter Aortic Valve Replacement. Indian heart journal, S0019-4832(24)00181-0. Advance online publication. https://doi.org/10.1016/j.ihj.2024.09.001
Disciplines
Medicine and Health Sciences
PubMedID
39322039
Department(s)
Fellows and Residents
Document Type
Article