let-7 miRNA controls CED-7 homotypic adhesion and EFF-1-mediated axonal self-fusion to restore touch sensation following injury

Authors

• Atrayee Basu
• Shirshendu Dey
• Dharmendra Puri
• Nilanjana Das Saha
• Vidur Sabharwal
• Pankajam Thyagarajan
• Prerna Srivastava
• Sandhya Padmanabhan Koushika
• Anindya Ghosh-Roy

Publication/Presentation Date

11-21-2017

Abstract

Neuronal injury often leads to devastating consequences such as loss of senses or locomotion. Restoration of function after injury relies on whether the injured axons can find their target cells. Although fusion between injured proximal axon and distal fragment has been observed in many organisms, its functional significance is not clear. Here, using

Volume

114

Issue

47

First Page

10206

Last Page

10206

ISSN

1091-6490

Published In/Presented At

Basu A, Dey S, Puri D, Das Saha N, Sabharwal V, Thyagarajan P, Srivastava P, Koushika SP, Ghosh-Roy A. let-7 miRNA controls CED-7 homotypic adhesion and EFF-1-mediated axonal self-fusion to restore touch sensation following injury. Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):E10206-E10215. doi: 10.1073/pnas.1704372114. Epub 2017 Nov 6. PMID: 29109254; PMCID: PMC5703274.

Disciplines

Medicine and Health Sciences

PubMedID

29109254

Department(s)

Hematology-Medical Oncology Division

Document Type

Article