Conditioning neoadjuvant therapies for improved immunotherapy of cancer.
Publication/Presentation Date
12-1-2017
Abstract
Recent advances in the treatment of melanoma and non-small cell lung cancer (NSCLC) by combining conventional therapies with anti-PD1/PD-L1 immunotherapies, have renewed interests in immunotherapy of cancer. The emerging concept of conventional cancer therapies combined with immunotherapy differs from the classical concept in that it is not simply taking advantage of their additive anti-tumor effects, but it is to use certain therapeutic regimens to condition the tumor microenvironment for optimal response to immunotherapy. To this end, low dose immunogenic chemotherapies, epigenetic modulators and inhibitors of cell cycle progression are potential candidates for rendering tumors highly responsive to immunotherapy. Next generation immunotherapeutics are therefore predicted to be highly effective against cancer, when they are used following appropriate immune modulatory compounds or targeted delivery of tumor cell cycle inhibitors using nanotechnology.
Volume
145
First Page
12
Last Page
17
ISSN
1873-2968
Published In/Presented At
Benson, Z., Manjili, S. H., Habibi, M., Guruli, G., Toor, A. A., Payne, K. K., & Manjili, M. H. (2017). Conditioning neoadjuvant therapies for improved immunotherapy of cancer. Biochemical pharmacology, 145, 12–17. https://doi.org/10.1016/j.bcp.2017.08.007
Disciplines
Medicine and Health Sciences
PubMedID
28803721
Department(s)
Department of Medicine, Hematology-Medical Oncology Division
Document Type
Article