Neurosurgical treatment of medically intractable status epilepticus.
Publication/Presentation Date
7-1-2001
Abstract
Medically intractable status epilepticus can be defined as status epilepticus (SE) that persists or recurs despite medical treatment with intravenous agents that suppress cortical activity. We describe the successful neurosurgical treatment of three patients with medically intractable status epilepticus who responded either to focal resection, multiple subpial transection, or callosal section. The duration of medically intractable status epilepticus before surgery ranged between 23 and 42 days, and multiple medical complications occurred during the failed medical therapy. We suggest that patients with medically intractable status epilepticus who fail to respond to three courses of cerebral suppressant therapy for approximately 2 weeks be considered for surgical treatment in the absence of any known remitting etiology. Focal resection and/or subpial transection is preferred for intractable partial SE with focal electrographic changes or a focal lesion demonstrated by structural or functional neuroimaging. Corpus callosotomy may be used for patients with generalized or non-localizable intractable status epilepticus.
Volume
46
Issue
1
First Page
33
Last Page
38
ISSN
0920-1211
Published In/Presented At
Ma, X., Liporace, J., O'Connor, M. J., & Sperling, M. R. (2001). Neurosurgical treatment of medically intractable status epilepticus. Epilepsy research, 46(1), 33–38. https://doi.org/10.1016/s0920-1211(01)00252-2
Disciplines
Medicine and Health Sciences
PubMedID
11395286
Department(s)
Department of Medicine
Document Type
Article