Experimental first-pass method for testing and comparing sorbent polymers used in the clearance of iodine contrast materials.
Publication/Presentation Date
1-1-2012
Abstract
BACKGROUND: Sorbents have been shown to adsorb iodinated radiocontrast media.
OBJECTIVE: In this study we describe a simple method to compare various sorbents in terms of capacity to adsorb radiocontrast media.
METHODS: Iodixanol solution was injected into columns filled with three types of sorbent at filtration velocities of increasing magnitude. Two variables of interest - contrast removal rate and matched iodine retention (MIR) - were calculated to measure the adsorption efficiency and the mass of contrast iodine adsorbed versus sorbent used, respectively.
RESULTS: The highest contrast removal and MIR for Porapak Q, CST 401 and Amberlite XAD4 were 41, 38 and 16% (p = 0.22 and 0.0005 for comparisons between Porapak Q-CST 401 and CST 401-Amberlite XAD4) and 0.060, 0.055 and 0.024, respectively (p = 0.18 and 0.0008). Extrapolation to a clinical scenario may suggest that removal of 8 ml iodixanol could be achieved by masses of sorbents of 43, 47 and 107 g, respectively.
CONCLUSION: In this study we set a benchmark for comparing the radiocontrast-adsorbing efficiency of polymer sorbents during first-pass experiments, using a readily available methodology.
Volume
34
Issue
1
First Page
34
Last Page
39
ISSN
1421-9735
Published In/Presented At
Angheloiu, G. O., Hänscheid, H., Wen, X., Capponi, V., Anderson, W. D., & Kellum, J. A. (2012). Experimental first-pass method for testing and comparing sorbent polymers used in the clearance of iodine contrast materials. Blood purification, 34(1), 34–39. https://doi.org/10.1159/000339816
Disciplines
Medicine and Health Sciences
PubMedID
22907199
Department(s)
Department of Medicine, Cardiology Division
Document Type
Article