Intrinsic versus laser-induced fluorescence spectroscopy for coronary atherosclerosis: a generational comparison model for testing diagnostic accuracy.
Publication/Presentation Date
12-1-2012
Abstract
Laser-induced fluorescence (LIF) and intrinsic fluorescence spectroscopy (IFS) have been used experimentally for diagnosing coronary atherosclerosis. In this study, we demonstrated the diagnostic superiority of IFS at 342-nm excitation (IFS(342)) versus LIF (LIF(342)) and described a protocol for head-to-head comparison of old (LIF) versus new (IFS) generations of similar diagnostic methods, labeled as "generational comparison model". IFS(342) and LIF(342) were modeled with basis spectra of media, fibrous caps, and superficial foam cells and of their correspondent chemicals (elastin, collagen, and lipoproteins). The average accuracy and receiver operating characteristic area under the curve of IFS(342) in single-, double-, and triple-parameter diagnostic algorithm iterations, geared toward identifying 84 atherosclerotic specimens from a group of 117 coronary segments, was 90% ± 1% and 0.87 ± 0.025, superior to LIF(342) (84% ± 3% and 0.84 ± 0.016; P = 0.0002 and 0.02, respectively) in a generational comparison model.
Volume
66
Issue
12
First Page
1403
Last Page
1410
ISSN
1943-3530
Published In/Presented At
Angheloiu, G. O., van de Poll, S. W., Georgakoudi, I., Motz, J. T., Haka, A. S., Podrez, E., Fitzmaurice, M., Dasari, R. R., Feld, M. S., & Kramer, J. R. (2012). Intrinsic versus laser-induced fluorescence spectroscopy for coronary atherosclerosis: a generational comparison model for testing diagnostic accuracy. Applied spectroscopy, 66(12), 1403–1410. https://doi.org/10.1366/11-06566
Disciplines
Medicine and Health Sciences
PubMedID
23231902
Department(s)
Department of Medicine, Cardiology Division
Document Type
Article