Severe topiramate-associated hyperthermia resulting in persistent neurological dysfunction.
Topiramate has recently been reported to cause hyperthermia as a result of oligohydrosis, primarily in pediatric patients. All cases reported to date were clinically mild, without permanent systemic or neurologic dysfunction. We report a case of severe hyperthermia and subsequent ataxia and tremor in an adult treated with topiramate. To our knowledge, this is the first case of topiramate-associated hyperthermia to result in residual cerebellar and cognitive dysfunction.
Published In/Presented At
Galicia, S. C., Lewis, S. L., & Metman, L. V. (2005). Severe topiramate-associated hyperthermia resulting in persistent neurological dysfunction. Clinical neuropharmacology, 28(2), 94–95. https://doi.org/10.1097/01.wnf.0000159957.95134.1b
Medicine and Health Sciences
Department of Medicine