Pneumococcal Sepsis-Induced Purpura Fulminans in an Asplenic Adult Patient Without Disseminated Intravascular Coagulation
Publication/Presentation Date
12-1-2013
Abstract
Acute perturbations in the hemostatic balance of anticoagulation and procoagulation antecede the manifestation of purpura fulminans, a rare syndrome of intravascular thrombosis and hemorrhagic infarction of the skin. Hallmarks include small vessel thrombosis, tissue necrosis and disseminated intravascular thrombosis. The course may be rapidly fulminant resulting in multiorgan failure with thrombotic occlusion of the vasculature, leading to distal extremity ischemia and necrosis. Depletion of protein C (PC) has been emphasized in the pathogenesis. Early intravenous antibiotic administration and hemodynamic support are cornerstones in management. Herein, we report a case of pneumococcal sepsis-induced purpura fulminans limited to the skin in an asplenic adult patient without the development disseminated intravascular coagulation.
Volume
346
Issue
6
First Page
514
Last Page
516
ISSN
1538-2990
Published In/Presented At
Saraceni, C., & Schwed-Lustgarten, D. (2013). Pneumococcal sepsis-induced purpura fulminans in an asplenic adult patient without disseminated intravascular coagulation. The American Journal Of The Medical Sciences, 346(6), 514-516. doi:10.1097/MAJ.0b013e31829e02d3
Disciplines
Bacterial Infections and Mycoses | Diseases | Medical Sciences | Medicine and Health Sciences
PubMedID
24185261
LVHN link
http://search.ebscohost.com/login.aspx?direct=true&db=mnh&AN=24185261&site=ehost-live&scope=site
Department(s)
Department of Medicine
Document Type
Article