Plasmablastic Lymphoma of the Maxillary Sinus in an HIV-negative Patient: a Case Report and Literature Review

Publication/Presentation Date

12-1-2013

Abstract

Plasmablastic lymphoma (PBL) is a rare and aggressive variant of diffuse large B cell lymphoma. The prognosis of PBL patients is poor. The majority of patients succumb to a fulminant disease course, with most dying in the first year after diagnosis. The small number of HIV-negative PBL cases reported in the literature to date is composed of single case reports and small case series. Consequently, the natural history of the disease in HIV-negative individuals and the optimum treatment are not well characterized. Intensive induction chemotherapy has been associated with marked improved overall survival. However the optimal regimen has not been defined. We describe the third case of PBL of the maxillary sinus which occurred in a 24-year old HIV-negative man. We outline the clinicopathological features and report success using a hyper-CVAD regimen with 6 cycles and consolidation radiation therapy yielding a complete remission of four years.

Volume

2

Issue

1

First Page

142

Last Page

142

ISSN

2193-1801

Disciplines

Hematology | Medical Sciences | Medical Specialties | Medicine and Health Sciences | Oncology | Pathology

PubMedID

23667804

Department(s)

Department of Medicine, Hematology-Medical Oncology Division, Department of Medicine Faculty, Department of Pathology and Laboratory Medicine

Document Type

Article

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