Diagnostic specificity of immunoglobulin M (IgM) response in differentiation Legionnaires' disease from psittacosis.
Publication/Presentation Date
1-1-1979
Abstract
Specific IgM and IgG antibody responses to Legionella pneumophila (LDB) and Chlamydia psittaci (PSI) in serum specimens from 22 cases of Legionnaires' Disease (LD) were examined by micro-immunofluorescence (IF) tests to explore the diagnostic significance of the IgM antibody response. Serial samples from 5 patients with LD showed greater than or equal to 4-fold changes in IgG antibody against LDB and PSI. All 5 patients possessed IgM antibodies against LDB but not against PSI. In single convalescent serum samples from 17 additional cases, 16 exhibited IgG and 15 showed IgM antibodies against LDB; all 17 exhibited IgG but not IgM antibodies against PSI. The IgM antibody response appears more specific than the corresponding IgG response in the serodiagnosis of LD, and may be valuable in differentiating LDB infections from those due to PSI.
Volume
11
Issue
4
First Page
271
Last Page
273
ISSN
0036-5548
Published In/Presented At
Lattimer, G. L., Ormsbee, R. A., Peacock, M. G., & Rhodes, L. V. (1979). Diagnostic specificity of immunoglobulin M (IgM) response in differentiation Legionnaires' disease from psittacosis. Scandinavian journal of infectious diseases, 11(4), 271–273. https://doi.org/10.3109/inf.1979.11.issue-4.03
Disciplines
Medicine and Health Sciences
PubMedID
394307
Department(s)
Department of Medicine
Document Type
Article