Clinical evaluation of netilmicin therapy in serious infections.
Publication/Presentation Date
1-1-1979
Abstract
Netilmicin, a new semisynthetic aminoglycoside, was evaluated in the therapy of 33 episodes of infection in 30 patients. Eighteen patients had documented bacteremia. Infection sites included pulmonary, urinary tract and soft tissue areas. A complete bacteriologic and clinical cure rate of 85 per cent was achieved. No treatment failures occurred in the bacteremic group. Although netilmicin is less effective than gentamicin in vitro against Pseudomonas, it was clinically and bacteriologically effective. Netilmicin bacteriologic cures occurred in patients whose organisms were inhibited by 6.2 microgram/ml or less of netilmicin. Despite a uniform dosing protocol, a wide range of netilmicin serum levels was obtained. Adverse effects were limited to one case of transient nephrotoxicity and one Candida urinary suprainfection. Netilmicin appears to be an effective, safe agent for the therapy of serious infections.
Volume
66
Issue
1
First Page
67
Last Page
73
ISSN
0002-9343
Published In/Presented At
Jahre, J. A., Fu, K. P., & Neu, H. C. (1979). Clinical evaluation of netilmicin therapy in serious infections. The American journal of medicine, 66(1), 67–73. https://doi.org/10.1016/0002-9343(79)90484-4
Disciplines
Medicine and Health Sciences
PubMedID
420253
Department(s)
Department of Medicine
Document Type
Article