Cholestyramine: use as a new therapeutic approach for chlordecone (kepone) poisoning.
In rats, as reported in humans, chlordecone (Kepone) is excreted predominantly in the feces. Cholestyramine, an anion exchange resin, binds chlordecone in rat intestine, increases its excretion into the feces, and decreases its content in the tissues. The resin appears to offer a practical method for treating chronic poisoning with this and possibly with other lipophilic toxins.
Published In/Presented At
Boylan, J. J., Egle, J. L., & Guzelian, P. S. (1978). Cholestyramine: use as a new therapeutic approach for chlordecone (kepone) poisoning. Science (New York, N.Y.), 199(4331), 893–895. https://doi.org/10.1126/science.74852
Medicine and Health Sciences
Department of Medicine