Title

An exaggerated augmentation of renal calcium excretion after oral glucose ingestion in patients with renal hypercalciuria.

Publication/Presentation Date

5-1-1978

Abstract

The calciuric response to an oral glucose load (100 g) was determined in 16 patients with calcium oxalate urolithiasis (seven with renal hypercalciuria and nine with absorptive hypercalciuria) and seven normal subjects. The rates of renal calcium excretion increased significantly after glucose ingestion in all three groups. The calciuric response in patients with absorptive hypercalciuria and intestinal hyperabsorption of calcium was indistinguishable from that of normal subjects. However, the calcium excretions were significantly higher during 1 hr preceding and 3 hr after glucose ingestion in patients with renal hypercalciuria (with presumed "renal leak" of calcium) than in normal subjects. The increment in the calcium excretion rate was also higher in patients with renal hyperacalciuria, particularly during the 2nd hour of glucose ingestion. The results provide a further support for the concept of different etiologies of renal and absorptive hypercalciurias.

Volume

15

Issue

6

First Page

486

Last Page

488

ISSN

0021-0005

Disciplines

Medicine and Health Sciences

PubMedID

348635

Department(s)

Department of Medicine

Document Type

Article

COinS