Immunoglobulins for intravenous use inhibit TNF alpha cytotoxicity in vitro.
Publication/Presentation Date
1-1-1997
Abstract
Intravenous immunoglobulins (IVIg) have been used as an immunomodulatory therapy in a variety of diseases. Several mechanisms of action have been proposed, one of which is interference with the cytokine network. We have investigated the effect of IVIg on the cytotoxicity of human TNF alpha. IVIg was capable of protecting L929 fibroblasts from TNF alpha induced cell death. This effect was not species specific and was mediated by both the Fc and the Fab portion of immunoglobulins. Since the effect was also seen when IVIg was added after the removal of TNF alpha from the culture medium, it seems to be independent of the interaction of TNF alpha with its receptor. We conclude that IVIg either act on some point of the TNF alpha signalling pathway or influence the cell cycle unspecifically. The cytoprotective effect of IVIg potentially could contribute to the beneficial effect described for various diseases.
Volume
26
Issue
5-7
First Page
569
Last Page
578
ISSN
0882-0139
Published In/Presented At
Stangel, M., Schumacher, H. C., Ruprecht, K., Boegner, F., & Marx, P. (1997). Immunoglobulins for intravenous use inhibit TNF alpha cytotoxicity in vitro. Immunological investigations, 26(5-7), 569–578. https://doi.org/10.3109/08820139709088541
Disciplines
Medicine and Health Sciences
PubMedID
9399100
Department(s)
Department of Medicine
Document Type
Article