Activation of plasma contact and coagulation systems and neutrophils in the active phase of ulcerative colitis.
Publication/Presentation Date
11-1-1997
Abstract
We have shown that the contact (kallikrein-kinin) system is involved in the pathogenesis of experimental enterocolitis. We now investigate activation of the contact and coagulation pathways, platelets, and neutrophils in active and inactive ulcerative colitis patients as compared to normal controls. In active ulcerative colitis patients, a significant decrease of plasma prekallikrein, high molecular weight kininogen, and C1 inhibitor levels was observed as compared with controls, as well as prekallikrein activation on western blots. Significant elevation of prothrombin fragment (F1 + 2), which indicates thrombin generation, and elastase-alpha 1-antitrypsin complexes, reflecting neutrophil activation, were found in patients with active disease. Plasma beta-thromboglobulin, a marker of platelet activation, was elevated in both active and inactive disease and appears to be a feature of ulcerative colitis. Activation of contact and coagulation pathways, as well as neutrophils, may mediate inflammation in the active phase of ulcerative colitis.
Volume
42
Issue
11
First Page
2356
Last Page
2366
ISSN
0163-2116
Published In/Presented At
Stadnicki, A., Gonciarz, M., Niewiarowski, T. J., Hartleb, J., Rudnicki, M., Merrell, N. B., Dela Cadena, R. A., & Colman, R. W. (1997). Activation of plasma contact and coagulation systems and neutrophils in the active phase of ulcerative colitis. Digestive diseases and sciences, 42(11), 2356–2366. https://doi.org/10.1023/a:1018891323205
Disciplines
Medicine and Health Sciences
PubMedID
9398817
Department(s)
Department of Medicine
Document Type
Article