Patient Preferences for Novel Therapy: An N-of-1 Trial of Garlic in the Treatment for Hypertension.
The authors used the N-of-1 clinical trial methodology to obtain insights about a patient's preference for garlic for the management of his hypertension. The 61-year-old man received garlic, 500 mg by mouth three times a day (3 weeks), or identical placebo (3 weeks) in three treatment pairs. While the patient was taking garlic the mean systolic blood pressure decreased by 2 mm Hg (95% confidence interval 0.4 to 4.7, p < 0.05), and the diastolic blood pressure decreased by 2.4 mm Hg (95% confidence interval 0.4 to 4, p < 0.025). The treatment effect of garlic was small, but the patient believed continuing garlic for the management of his hypertension was justified.
Published In/Presented At
Estrada, C. A., & Young, M. J. (1993). Patient preferences for novel therapy: an N-of-1 trial of garlic in the treatment for hypertension. Journal Of General Internal Medicine, 8(11), 619-621.
Medical Sciences | Medicine and Health Sciences
Department of Medicine, Department of Medicine Faculty