An animal model of focal, subacute, viral retinitis.
Publication/Presentation Date
1-1-1993
Abstract
To study local intravitreal therapies for retinitis due to herpes viruses, an animal model of focal, subacute, relatively nonlethal herpes family retinitis is needed. Herpes simplex virus type 1 (HSV-1) was injected into the subretinal space of 33 Dutch pigmented rabbit eyes. The animals were observed for up to 42 days after the inoculation. All inoculated eyes developed a focal, enlarging area of retinitis in a predictable manner, showing focal enlarging areas of retinal opacification and necrosis with variable retinal hemorrhage. In the inoculated eyes, retinal detachment developed in all animals within 21 days; 33% of the animals developed focal retinitis in the uninoculated eye. Histologic examination showed encephalitis to be present in 11 (73%) of the 15 animals studied after 1 week. This model may be used to evaluate the therapeutic efficacy of new antiviral agents and modalities in the treatment of herpes family viral retinitis. The model is most similar to herpes simplex or zoster retinitis in humans, but also shares some similarities (and differences) with cytomegalovirus (CMV) retinitis in humans.
Volume
13
Issue
3
First Page
214
Last Page
221
ISSN
0275-004X
Published In/Presented At
Freeman, W. R., Schneiderman, T. E., Wiley, C. A., Listhaus, A. D., Svendsen, P., Munguia, D., & Bergeron-Lynn, G. (1993). An animal model of focal, subacute, viral retinitis. Retina (Philadelphia, Pa.), 13(3), 214–221. https://doi.org/10.1097/00006982-199313030-00005
Disciplines
Medicine and Health Sciences
PubMedID
8235102
Department(s)
Department of Medicine
Document Type
Article