Effects of barium on isolated frog spinal cord.
Publication/Presentation Date
1-1-1986
Abstract
The effects of Ba2+ were studied in vitro on the isolated frog spinal cord. Ba2+ (25 microM-5 mM) caused a concentration-dependent depolarization of ventral (VR) and dorsal (DR) roots. TTX and Mg2+ substantially reduced the depolarization suggesting that interneuronal effects were involved. Ba2+ (25-500 microM) markedly increased the frequency and duration of spontaneous VR and DR potentials and substantially enhanced the duration (and frequently the amplitude) of VR and DR potentials evoked by DR stimulation. Higher concentrations of Ba2+ (1-5 mM) reduced both spontaneous and evoked potentials. Ba2+ (25-500 microM) enhanced the amount of K+ released by a DR volley and by application of L-glutamate and L-aspartate. The cation reduced VR and DR root depolarizations produced by elevated [K+]0. VR potentials induced by L-glutamate, L-aspartate, GABA and glycine and DR depolarizations caused by GABA were reduced by Ba2+. These results show that Ba2+ has complex actions on reflex transmission, interneuronal activity, the postsynaptic actions of excitatory and inhibitory amino acids and the evoked release of K+.
Volume
85
Issue
1
First Page
49
Last Page
56
ISSN
0742-8413
Published In/Presented At
Hackman, J. C., Ryan, G. P., Wohlberg, C. J., & Davidoff, R. A. (1986). Effects of barium on isolated frog spinal cord. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 85(1), 49–56. https://doi.org/10.1016/0742-8413(86)90050-2
Disciplines
Medicine and Health Sciences
PubMedID
2877804
Department(s)
Department of Medicine
Document Type
Article