Race and delayed kidney allograft function.
Publication/Presentation Date
3-1-1998
Abstract
BACKGROUND: Allograft survival among black recipients is poorer than among whites. Delayed allograft function is associated with a significant reduction in renal allograft survival. The relationship between delayed allograft function and black race is incompletely specified and was the focus of this investigation.
METHODS: A non-concurrent study of 325 recipients of cadaveric allografts followed for the occurrence of delayed allograft function defined as dialysis during the first week following transplantation for the principal analysis. A secondary definition of delayed allograft function was formulated based on the serum creatinine 2 weeks after transplantation. Unadjusted and adjusted logistic regression analysis were used to examine the unconfounded relationship between race and delayed allograft function.
RESULTS: Fifty-seven of 91 (62.6%) black recipients experienced delayed allograft function compared to 113 of 234 (48.3%) whites. The odds ratio for black race as a predictor of delayed allograft function was 1.80, P=0.02, (95% CI, 1.09, 2.95). This finding was stable despite adjustment for other predictors of delayed allograft function in a multivariate model, but the precision of this estimate was less (P=0.10) because of missing data. Additionally, adjusted models with imputed values for missing covariates, models using a secondary definition of delayed allograft function, and models excluding patients whose cyclosporin therapy was delayed, all consistently demonstrated a similar association between black race and delayed allograft function.
CONCLUSIONS: This study demonstrated an increased risk of delayed allograft function among black recipients. This relationship may play a role in the poorer allograft outcomes experienced by black recipients. Given the negative effect of delayed allograft function on allograft survival, efforts to identify its modifiable risk factors should be a high priority.
Volume
13
Issue
3
First Page
704
Last Page
710
ISSN
0931-0509
Published In/Presented At
Feldman, H. I., Burns, J. E., Roth, D. A., Berlin, J. A., Szczech, L., Gayner, R., Kushner, S., Brayman, K. L., & Grossman, R. A. (1998). Race and delayed kidney allograft function. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 13(3), 704–710. https://doi.org/10.1093/ndt/13.3.704
Disciplines
Medicine and Health Sciences
PubMedID
9550650
Department(s)
Department of Medicine
Document Type
Article