Cardiac Magnetic Resonance Studies in a Large Animal Model That Simulates the Cardiac Abnormalities of Human Septic Shock.
Publication/Presentation Date
8-6-2024
Abstract
BACKGROUND: Septic shock is associated with increases in end-diastolic volume (EDV) and decreases in ejection fraction that reverse within 10 days. Nonsurvivors do not develop EDV increases. The mechanism is unknown.
METHODS AND RESULTS: Purpose-bred beagles (n=33) were randomized to receive intrabronchial
CONCLUSIONS: The cardiac dysfunction of sepsis is associated with wall edema. In nonsurvivors, at 0 to 24 hours, sepsis induces a more severe diastolic dysfunction, further decreasing chamber size. The loss of left ventricular mass with wall thinning in septic survivors may, in part, explain the EDV increases from 24 to 48 hours because of a potentially reparative process removing damaged wall tissue. Septic cardiomyopathy is most consistent with a nonocclusive microvascular injury resulting in edema causing reversible systolic and diastolic dysfunction with more severe diastolic dysfunction being associated with a decreased EDV and death.
Volume
13
Issue
15
First Page
034026
Last Page
034026
ISSN
2047-9980
Published In/Presented At
Ford, V. J., Applefeld, W. N., Wang, J., Sun, J., Solomon, S. B., Sidenko, S., Feng, J., Sheffield, C., Klein, H. G., Yu, Z. X., Torabi-Parizi, P., Danner, R. L., Sachdev, V., Solomon, M. A., Chen, M. Y., & Natanson, C. (2024). Cardiac Magnetic Resonance Studies in a Large Animal Model that Simulates the Cardiac Abnormalities of Human Septic Shock. bioRxiv : the preprint server for biology, 2024.02.05.578971. https://doi.org/10.1101/2024.02.05.578971
Disciplines
Medicine and Health Sciences
PubMedID
39101510
Department(s)
Department of Medicine
Document Type
Article