Cardiac Magnetic Resonance Studies in a Large Animal Model that Simulates the Cardiac Abnormalities of Human Septic Shock.
Publication/Presentation Date
2-8-2024
Abstract
BACKGROUND: Septic shock, in humans and in our well-established animal model, is associated with increases in biventricular end diastolic volume (EDV) and decreases in ejection fraction (EF). These abnormalities occur over 2 days and reverse within 10 days. Septic non-survivors do not develop an increase in EDV. The mechanism for this cardiac dysfunction and EDV differences is unknown.
METHODS: Purpose-bred beagles randomized to receive intrabronchial
RESULTS: From 0-96h after bacterial challenge, septic animals
CONCLUSION: Systolic and diastolic cardiac dysfunction during sepsis is associated with ventricular wall edema. Rather than differences in preload, afterload, or heart rate, structural alterations to the ventricular wall best account for the volume changes associated with outcome during sepsis. In non-survivors, from 0-24h, sepsis induces a more severe diastolic dysfunction, further decreasing chamber size. The loss of left ventricular mass with wall thinning in septic survivors may, in part explain, the EDV increases from 24-48h. However, these changes continued and even accelerated into the recovery phase consistent with a reparative process rather than ongoing injury.
ISSN
2692-8205
Published In/Presented At
Ford, V. J., Applefeld, W. N., Wang, J., Sun, J., Solomon, S. B., Sidenko, S., Feng, J., Sheffield, C., Klein, H. G., Yu, Z. X., Torabi-Parizi, P., Danner, R. L., Sachdev, V., Solomon, M. A., Chen, M. Y., & Natanson, C. (2024). Cardiac Magnetic Resonance Studies in a Large Animal Model that Simulates the Cardiac Abnormalities of Human Septic Shock. bioRxiv : the preprint server for biology, 2024.02.05.578971. https://doi.org/10.1101/2024.02.05.578971
Disciplines
Medicine and Health Sciences
PubMedID
38903100
Department(s)
Fellows and Residents
Document Type
Article