Does nitroglycerin induce heparin resistance?
Publication/Presentation Date
8-1-1989
Abstract
We studied the possibility that intravenous nitroglycerin may produce heparin resistance both in vitro and prospectively in a group of 10 patients following coronary angioplasty. Nitroglycerin in physiologic to pharmacologic concentrations (41-250 micrograms/ml) did not produce heparin resistance in vitro as measured by activated partial thromboplastin time and thrombin time. The maximum reduction in activated partial thromboplastin time was 7%. In patient studies, the activated partial thromboplastin time at baseline on heparin alone (93 + 22 s) was not significantly different (p = 0.61) from activated partial thromboplastin measured upon addition of nitroglycerin (94 +/- 27 s) or 30 min following cessation of the nitroglycerin infusion while continuing the same dose of heparin (91 +/- 24 s). We conclude that intravenous nitroglycerin does not induce heparin resistance in vitro or in patients during short-term administration.
Volume
12
Issue
8
First Page
432
Last Page
434
ISSN
0160-9289
Published In/Presented At
Lepor, N. E., Amin, D. K., Berberian, L., & Shah, P. K. (1989). Does nitroglycerin induce heparin resistance?. Clinical cardiology, 12(8), 432–434. https://doi.org/10.1002/clc.4960120806
Disciplines
Medicine and Health Sciences
PubMedID
2527661
Department(s)
Department of Medicine
Document Type
Article