Pentoxifylline increases retinal capillary blood flow velocity in patients with diabetes.
Publication/Presentation Date
12-1-1993
Abstract
OBJECTIVE: The purpose of this study was to determine whether oral pentoxifylline would improve retinal microvascular hemodynamics and blood rheology in patients with diabetes.
DESIGN: Patients were enrolled in a double-masked, placebo-controlled trial of pentoxifylline at 2000 mg/d. Retinal capillary blood velocity and leukocyte density, filterability, viscosity, and fibrinogen content were measured by the blue-field entoptic phenomenon simulation, filtration, rotational viscosimetry, and heat precipitation techniques, respectively, before, during, and after drug therapy.
RESULTS: Treatment with pentoxifylline resulted in a 23.2%, 26.8%, and 37.8% increase in capillary blood flow velocity at 1, 2, and 3 months of therapy, respectively, with a return to pretreatment baseline levels 1 month after cessation of therapy. There were no apparent effects on the remaining variables during treatment.
CONCLUSION: Pentoxifylline increases retinal capillary blood flow velocity in patients with diabetes.
Volume
111
Issue
12
First Page
1647
Last Page
1652
ISSN
0003-9950
Published In/Presented At
Sonkin, P. L., Kelly, L. W., Sinclair, S. H., & Hatchell, D. L. (1993). Pentoxifylline increases retinal capillary blood flow velocity in patients with diabetes. Archives of ophthalmology (Chicago, Ill. : 1960), 111(12), 1647–1652. https://doi.org/10.1001/archopht.1993.01090120069024
Disciplines
Medicine and Health Sciences
PubMedID
8155035
Department(s)
Department of Medicine
Document Type
Article