The effect of pentoxifylline on retinal capillary blood flow velocity and whole blood viscosity.
Publication/Presentation Date
6-15-1993
Abstract
Ten normal, healthy, nonsmoking volunteers participated in a double-masked, placebo-controlled one-day trial of 2,000 mg of oral pentoxifylline to determine the short-term effects of orally administered pentoxifylline on retinal circulation and rheologic properties of whole blood. Retinal capillary blood velocity and leukocyte density, whole blood viscosity, and whole blood filterability were measured before and after therapy by the blue-field entoptic phenomenon computer simulation, rotational viscometry, and micropore filtration techniques, respectively. Treatment with pentoxifylline for one day resulted in a significant improvement in retinal capillary blood flow velocity (P = .02) and in viscosity (P < .01), but not filterability, of whole blood. These results suggest that pentoxifylline may be useful in the treatment of early diabetic retinopathy.
Volume
115
Issue
6
First Page
775
Last Page
780
ISSN
0002-9394
Published In/Presented At
Sonkin, P. L., Sinclair, S. H., & Hatchell, D. L. (1993). The effect of pentoxifylline on retinal capillary blood flow velocity and whole blood viscosity. American journal of ophthalmology, 115(6), 775–780. https://doi.org/10.1016/s0002-9394(14)73647-5
Disciplines
Medicine and Health Sciences
PubMedID
8506913
Department(s)
Department of Medicine
Document Type
Article