Effect of panretinal photocoagulation on retinal blood flow in proliferative diabetic retinopathy.
Publication/Presentation Date
5-1-1986
Abstract
The effect of panretinal photocoagulation (PRP) on retinal volumetric blood flow rate and its regulatory response to hyperoxia was investigated in a main temporal vein of 15 eyes with proliferative diabetic retinopathy, using bi-directional laser Doppler velocimetry and monochromatic fundus photography. At an average of 4 +/- 2 months after the beginning of PRP, retinal venous diameter decreased from an average of 174 +/- 20 micron to 162 +/- 19 micron (P less than 0.01), red blood cell velocity decreased from 1.3 +/- 0.4 cm/sec to 1.1 +/- 0.4 cm/sec (P less than 0.01), and blood flow decreased from 11.5 +/- 3.8 microliter/min to 8.4 +/- 3.3 microliter/min (P less than 0.001). The regulatory response to hyperoxia, characterized by the percentage decrease in retinal blood flow during 100% oxygen breathing, improved from 20 +/- 15% prior to treatment to 45 +/- 12% following treatment (P less than 0.001). The decrease in retinal blood flow is most likely due to a decrease in viable retinal tissue and an improvement in retinal oxygenation following PRP. The increase in the regulatory response to 100% O2 breathing following PRP may also result from such an improved retinal oxygenation.
Volume
93
Issue
5
First Page
590
Last Page
595
ISSN
0161-6420
Published In/Presented At
Grunwald, J. E., Riva, C. E., Brucker, A. J., Sinclair, S. H., & Petrig, B. L. (1986). Effect of panretinal photocoagulation on retinal blood flow in proliferative diabetic retinopathy. Ophthalmology, 93(5), 590–595. https://doi.org/10.1016/s0161-6420(86)33691-1
Disciplines
Medicine and Health Sciences
PubMedID
3725318
Department(s)
Department of Medicine
Document Type
Article