[In vitro stimulation of peripheral blood lymphocytes with allogeneic lymphocytes (mixed lymphocyte culture, MLC) or phytomitogens in patients with Hashimoto's thyroiditis (author's transl)].
Publication/Presentation Date
9-20-1978
Abstract
To investigate the role of peripheral blood lymphocytes in thyroid auto-immunity, the in vitro responsiveness to allogeneic lymphocytes (MLC) or phytomitogens was examined in the lymphocytes from patients with Hashimoto's thyroiditis. The MLC responses of 16 patients were compared with those of age- and sex-matched normal controls. All possible combinations between lymphocytes from the patients and controls were mixed in both one-way and two-way MLC. From the results of one-way MLC, the stimulatory capacity and responding capacity of lymphocytes from the patients and controls were calculated respectively as follows: : formula: (see text) To the same allogeneic stimulation of Nm (mitomycin-treated stimulating lymphocytes from controls), lymphocytes from the patients (H) exhibited a lower response (P greater than 0.05) than did those from the controls (compare (1) with (3)). Phytomitogen-response was simultaneously studied for residual cells of MLC. Lymphocytes from the patients showed a significantly decreased (P less than 0.01) response to phytohemagglutinin-p and concanavalin A in comparison with the response of normal lymphocytes. From these results, it was suggested that cell-mediated immunity in vivo was impaired in Hishimoto's thyroiditis.
Volume
54
Issue
9
First Page
1030
Last Page
1042
ISSN
0029-0661
Published In/Presented At
Naeye, R. L., Mahon, J. K., & Dellinger, W. S. (1971). Rank of coal and coal workers pneumoconiosis. The American review of respiratory disease, 103(3), 350–355. https://doi.org/10.1164/arrd.1971.103.3.350
Disciplines
Medicine and Health Sciences
PubMedID
152720
Department(s)
Department of Medicine
Document Type
Article