Controlled ovarian hyperstimulation does not adversely affect endometrial receptivity in in vitro fertilization cycles.
Publication/Presentation Date
10-1-2001
Abstract
OBJECTIVE: To determine whether exposure of developing endometrium to supraphysiologic E2 levels during controlled ovarian hyperstimulation (COH) in IVF cycles inhibits endometrial receptivity.
DESIGN: Retrospective analysis of IVF-ET and ovum donation data.
SETTING: Tertiary-care teaching hospital.
PATIENT(S): Four hundred ten patients(age) and their associated ovum recipients.
MAIN OUTCOME MEASURE(S): Implantation, pregnancy, and delivery rates.
RESULT(S): Ovarian response to COH (duration of stimulation, peak E2 level, area under the curve for E2 exposure, and number of oocytes retrieved) was similar for IVF-ET patients and ovum donors. Donors were younger than IVF-ET patients (mean age, 27.5 +/- 0.2 years vs. 30.4 +/- 0.1 years). A similar number of embryos with similar number of blastomeres were transferred in IVF-ET patients and ovum recipients. The fragmentation rate at time of transfer differed slightly between groups (5.2 +/- 0.2% vs. 4.3 +/- 0.3%). Implantation, pregnancy, and delivery rates did not differ between IVF-ET patients and recipients of donor oocytes.
CONCLUSION(S): Exposure of the developing endometrium to controlled ovarian hyperstimulation during IVF cycles does not inhibit embryo implantation or affect pregnancy and delivery rates.
Volume
76
Issue
4
First Page
670
Last Page
674
ISSN
0015-0282
Published In/Presented At
Levi, A. J., Drews, M. R., Bergh, P. A., Miller, B. T., & Scott, R. T., Jr (2001). Controlled ovarian hyperstimulation does not adversely affect endometrial receptivity in in vitro fertilization cycles. Fertility and sterility, 76(4), 670–674. https://doi.org/10.1016/s0015-0282(01)01988-4
Disciplines
Medicine and Health Sciences
PubMedID
11591397
Department(s)
Department of Obstetrics and Gynecology
Document Type
Article