Treatment of vocal fold scarring: rheological and histological measures of homologous collagen matrix.

Publication/Presentation Date

10-1-2002

Abstract

The current treatment options for dysphonia secondary to vocal fold scarring are limited. Few studies address changes in the lamina propria, which is critical to vocal fold biomechanical properties and voice production. Using rheological and histological measures of homologous collagen matrix (HCM)-injected vocal folds, we assessed HCM's potential for providing bulk and restoring biomechanical performance. Twenty rabbits underwent bilateral vocal fold scarring. After 10 weeks of scar maturation, the rabbits had unilateral injections of HCM or saline solution. Ten weeks after the injections, histological studies revealed well-defined collagen globules distributed throughout the lamina propria and underlying muscular tissue. Significantly more procollagen was observed in the HCM-treated group. No significant differences in elastic shear modulus or dynamic viscosity were found between the treatment groups. This study demonstrates that HCM is an inert, relatively stable injectate that may serve well for medialization but does not appear to improve the dynamic properties of the lamina propria.

Volume

111

Issue

10

First Page

884

Last Page

889

ISSN

0003-4894

Disciplines

Medicine and Health Sciences | Otolaryngology

PubMedID

12389855

Department(s)

Division of Otolaryngology

Document Type

Article

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