Colon cancer bearing rats produce a lymphokine which induces macrophage migration inhibition (MIF) in vitro.
Publication/Presentation Date
1-1-1988
Abstract
We studied a series of 40 rats at various stages of colorectal carcinoma, as induced by N-methyl-N-nitro-Nitrosoguanidine. Lymphokine containing supernatants were obtained simultaneously from splenic and peripheral lymphocytes, after exposure to rat colon cancer antigen in vitro. The lymphokine was found capable of performing Macrophage Migration Inhibition (MIF) when obtained from rats with: carcinoma through serosa, carcinoma of submucosa, carcinoma of the mucosa and carcinoma in situ. All control rats were free of cancer and were MIF negative. The MIF response in this study was evaluated as a marker of chemically induced colorectal carcinoma in rats in order to better understand the lymphocyte response to tumor progression from atypia to adenocarcinoma of the colon.
Volume
11
Issue
1
First Page
61
Last Page
69
ISSN
0147-9571
Published In/Presented At
Reshef, R., Livni, E., Lachter, J., Suprun, H., Eidelman, S., & Shkolnik, T. (1988). Colon cancer bearing rats produce a lymphokine which induces macrophage migration inhibition (MIF) in vitro. Comparative immunology, microbiology and infectious diseases, 11(1), 61–69. https://doi.org/10.1016/0147-9571(88)90009-4
Disciplines
Medicine and Health Sciences
PubMedID
3289827
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article