Phenotypic and population differences in the association between CILP and lumbar disc disease.
Publication/Presentation Date
4-1-2007
Abstract
BACKGROUND: Lumbar disc disease (LDD) is one of the leading causes of disability in the working-age population. A functional single-nucleotide polymorphism (SNP), +1184T-->C, in exon 8 of the cartilage intermediate layer protein gene (CILP) was recently identified as a risk factor for LDD in the Japanese population (odds ratio (OR) 1.61, 95% CI 1.31 to 1.98), with implications for impaired transforming growth factorbeta1 signalling.
AIM: To validate this finding in two different ethnic cohorts with LDD.
METHODS: This SNP and flanking SNPs were analysed in 243 Finnish patients with symptoms of LDD and 259 controls, and in 348 Chinese subjects with MRI-defined LDD and 343 controls.
RESULTS AND CONCLUSION: The results showed no evidence of association in the Finnish (OR = 1.35, 95% CI 0.97 to 1.87; p = 0.14) or the Chinese (OR = 1.05, 95% CI 0.77 to 1.43; p = 0.71) samples, suggesting that cartilage intermediate layer protein gene is not a major risk factor for symptoms of LDD in Caucasians or in the general population that included individuals with or without symptoms.
Volume
44
Issue
4
First Page
285
Last Page
288
ISSN
1468-6244
Published In/Presented At
Virtanen, I. M., Song, Y. Q., Cheung, K. M., Ala-Kokko, L., Karppinen, J., Ho, D. W., Luk, K. D., Yip, S. P., Leong, J. C., Cheah, K. S., Sham, P., & Chan, D. (2007). Phenotypic and population differences in the association between CILP and lumbar disc disease. Journal of medical genetics, 44(4), 285–288. https://doi.org/10.1136/jmg.2006.047076
Disciplines
Medicine and Health Sciences
PubMedID
17220213
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article