Analysis of an ascidian integrin provides new insight into early evolution of collagen recognition.
Publication/Presentation Date
5-29-2007
Abstract
AlphaI domain integrins have been found in the ascidian Ciona intestinalis. We produced Ciona alpha1I domain as a recombinant protein. It did not recognize fibril-forming collagens or bind to GFOGER or other similar motifs in triple-helical peptides. No GFOGER motifs were found in Ciona collagens. As Ciona alpha1I bound to collagen IX, we propose that before the emergence of GFOGER-dependent collagen receptors in vertebrates, alphaI domain integrins might have been able to bind to collagen with alternative mechanisms.
Volume
581
Issue
13
First Page
2434
Last Page
2440
ISSN
0014-5793
Published In/Presented At
Tulla, M., Huhtala, M., Jäälinoja, J., Käpylä, J., Farndale, R. W., Ala-Kokko, L., Johnson, M. S., & Heino, J. (2007). Analysis of an ascidian integrin provides new insight into early evolution of collagen recognition. FEBS letters, 581(13), 2434–2440. https://doi.org/10.1016/j.febslet.2007.04.054
Disciplines
Medicine and Health Sciences
PubMedID
17485091
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article