Immune responses and their regulation by donor bone marrow cells in clinical organ transplantation.
Publication/Presentation Date
1-1-2003
Abstract
Infusions of donor bone marrow derived cells (DBMC) continue to be tested in clinical protocols intended to induce specific immunologic tolerance of solid organ transplants based on the observations that donor-specific tolerance is induced this way in animal models. We studied the immunological effects of human DBMC infusions in renal transplantation using modifications in lymphoproliferation (MLR) and cytotoxicity (CML) assays. The salient observations and tentative conclusions are summarized in this review. Among many types of organs transplanted using DBMC at this center, it was found that the cadaver renal recipients (CAD) had significantly decreased chronic rejection and higher graft survival when compared to equivalent non-infused controls. DBMC infusion was also associated with a marginal and non-specific immune depression. It was also observed that the number of chimeric donor cells gradually increased in the iliac crest bone marrow compartment with a concomitant decrease in the peripheral blood and that the increase was more rapid in living-related donor (LRD)-kidney/DBMC recipients in spite of a lower number of DBMC infused (
Volume
11
Issue
3-4
First Page
307
Last Page
321
ISSN
0966-3274
Published In/Presented At
Mathew, J. M., Garcia-Morales, R. O., Carreno, M., Jin, Y., Fuller, L., Blomberg, B., Cirocco, R., Burke, G. W., Ciancio, G., Ricordi, C., Esquenazi, V., Tzakis, A. G., & Miller, J. (2003). Immune responses and their regulation by donor bone marrow cells in clinical organ transplantation. Transplant immunology, 11(3-4), 307–321. https://doi.org/10.1016/S0966-3274(03)00056-X
Disciplines
Medicine and Health Sciences
PubMedID
12967784
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article