Adenovirus infection in pediatric liver and intestinal transplant recipients: utility of DNA detection by PCR.
Publication/Presentation Date
2-1-2003
Abstract
To evaluate the incidence of adenovirus (AdV) infection in pediatric liver and intestinal transplant recipients, the records of patients with possible AdV infection were reviewed for demographic data, symptomatology, methods of diagnosis, treatment and outcome. To evaluate the impact of polymerase chain reaction (PCR) amplification and identification of AdV DNA as a diagnostic test, the incidence and outcome of AdV before and after the introduction of PCR were compared. Adenovirus infection was identified in 4.1% of liver recipients and 20.8% of intestinal transplant recipients. The overall incidence of AdV did not increase over time, even following the introduction of PCR for virus detection. The higher incidence of AdV in the pediatric intestinal transplant recipients may be attributed to the frequent application of PCR methodology to intestinal biopsy material. Detection of AdV by PCR was associated with reduced mortality compared with detection by culture, either because of earlier detection of invasive disease or because PCR detects the presence of latent as well as active AdV.
Volume
3
Issue
2
First Page
224
Last Page
228
ISSN
1600-6135
Published In/Presented At
McLaughlin, G. E., Delis, S., Kashimawo, L., Cantwell, G. P., Mittal, N., Cirocco, R. E., Ruiz, P., Kato, T., & Tzakis, A. G. (2003). Adenovirus infection in pediatric liver and intestinal transplant recipients: utility of DNA detection by PCR. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 3(2), 224–228. https://doi.org/10.1034/j.1600-6143.2003.00007.x
Disciplines
Medicine and Health Sciences
PubMedID
12603217
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article