The Synthetic Small Molecule FL3 Combats Intestinal Tumorigenesis via Axin1-Mediated Inhibition of Wnt/β-Catenin Signaling.

Authors

Dakota N Jackson
Kibrom M Alula
Yaritza Delgado-Deida
Redouane Tabti
Kevin Turner
Xuan Wang
K Venuprasad
Rhonda F Souza
Laurent Désaubry
Arianne L Theiss

Publication/Presentation Date

9-1-2020

Abstract

Colorectal cancer exhibits aberrant activation of Wnt/β-catenin signaling. Many inhibitors of the Wnt/β-catenin pathway have been tested for Wnt-dependent cancers including colorectal cancer, but are unsuccessful due to severe adverse reactions. FL3 is a synthetic derivative of natural products called flavaglines, which exhibit anti-inflammatory and cytoprotective properties in intestinal epithelial cells, but has not been previously tested in cell or preclinical models of intestinal tumorigenesis.

Volume

80

Issue

17

First Page

3519

Last Page

3529

ISSN

1538-7445

Published In/Presented At

Jackson, D. N., Alula, K. M., Delgado-Deida, Y., Tabti, R., Turner, K., Wang, X., Venuprasad, K., Souza, R. F., Désaubry, L., & Theiss, A. L. (2020). The Synthetic Small Molecule FL3 Combats Intestinal Tumorigenesis via Axin1-Mediated Inhibition of Wnt/β-Catenin Signaling. Cancer research, 80(17), 3519–3529. https://doi.org/10.1158/0008-5472.CAN-20-0216

Disciplines

Medicine and Health Sciences

PubMedID

32665357

Department(s)

Department of Pathology and Laboratory Medicine

Document Type

Article