Mitochondrial dysfunction during loss of prohibitin 1 triggers Paneth cell defects and ileitis.
Publication/Presentation Date
11-1-2020
Abstract
OBJECTIVE: Although perturbations in mitochondrial function and structure have been described in the intestinal epithelium of Crohn's disease and ulcerative colitis patients, the role of epithelial mitochondrial stress in the pathophysiology of inflammatory bowel diseases (IBD) is not well elucidated. Prohibitin 1 (PHB1), a major component protein of the inner mitochondrial membrane crucial for optimal respiratory chain assembly and function, is decreased during IBD.
DESIGN: Male and female mice with inducible intestinal epithelial cell deletion of
RESULTS:
CONCLUSION: Our results identify Paneth cells as highly susceptible to mitochondrial dysfunction and central to the pathogenesis of ileitis, with translational implications for the subset of Crohn's disease patients exhibiting Paneth cell defects.
Volume
69
Issue
11
First Page
1928
Last Page
1938
ISSN
1468-3288
Published In/Presented At
Jackson, D. N., Panopoulos, M., Neumann, W. L., Turner, K., Cantarel, B. L., Thompson-Snipes, L., Dassopoulos, T., Feagins, L. A., Souza, R. F., Mills, J. C., Blumberg, R. S., Venuprasad, K., Thompson, W. E., & Theiss, A. L. (2020). Mitochondrial dysfunction during loss of prohibitin 1 triggers Paneth cell defects and ileitis. Gut, 69(11), 1928–1938. https://doi.org/10.1136/gutjnl-2019-319523
PubMedID
32111635
Document Type
Article