Cisapride in Gastro-Oesophageal Reflux Disease: Effects on Oesophageal Motility and Intra-Oesophageal pH

Publication/Presentation Date

1989

Abstract

Abstract

Since gastro-oesophageal reflux disease is due to disturbances of oesophageal motility, motor and pH measurements are an important means to test a new anti-reflux drug, cisapride. In oesophageal manometry cisapride increased the pressure of the lower oesophageal sphincter in healthy volunteers and patients, and in the majority of studies it also strengthened the amplitude of oesophageal contractions. Cisapride lowered the total duration of acid exposure in the lower oesophagus in both volunteers and reflux patients. Thus cisapride may be useful in the treatment of gastro-oesophageal reflux disease.

Volume

24

First Page

13

Last Page

18

Comments

Issue Sup165

Medicom Europe

Disciplines

Medical Pathology | Pathology

Department(s)

Department of Medicine, Department of Pathology and Laboratory Medicine

Document Type

Article

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