Activation of nevi in patients with malignant melanoma.
Publication/Presentation Date
8-15-1980
Abstract
Activation of melanocytic nevi from patients with malignant melanoma is documented microscopically. Features of activation include marked junctional activity, lack of lateral margination of junctional melanocytic activity, and--to a lesser degree--increased pigment production, inflammation, mitotic activity, and cytologic atypia. The changes are most pronounced in nevi from the same lymph drainage region as the malignant melanoma, suggesting a local activating factor. The presence of marked junctional activity in these lesions and the occurrence of these changes in nevi of patients with clinical Stage I malignant melanomas provide evidence that these lesions do not represent metastases.
Volume
46
Issue
4
First Page
822
Last Page
827
ISSN
0008-543X
Published In/Presented At
Tucker, S. B., Horstmann, J. P., Hertel, B., Aranha, G., & Rosai, J. (1980). Activation of nevi in patients with malignant melanoma. Cancer, 46(4), 822–827. https://doi.org/10.1002/1097-0142(19800815)46:4<822::aid-cncr2820460430>3.0.co;2-p
Disciplines
Medicine and Health Sciences
PubMedID
7397646
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article