Carbapenemase production among less-common Enterobacterales genera: 10 US sites, 2018.
Publication/Presentation Date
9-1-2021
Abstract
BACKGROUND: Historically, United States' carbapenem-resistant Enterobacterales (CRE) surveillance and mechanism testing focused on three genera:
OBJECTIVES: From January through May 2018, we conducted a 10 state evaluation to assess the contribution of less common genera (LCG) to carbapenemase-producing (CP) CRE.
METHODS: State public health laboratories (SPHLs) requested participating clinical laboratories submit all Enterobacterales from all specimen sources during the surveillance period that were resistant to any carbapenem (Morganellaceae required resistance to doripenem, ertapenem, or meropenem) or were CP based on phenotypic or genotypic testing at the clinical laboratory. SPHLs performed species identification, phenotypic carbapenemase production testing, and molecular testing for carbapenemases to identify CP-CRE. Isolates were categorized as CP if they demonstrated phenotypic carbapenemase production and ≥1 carbapenemase gene (
RESULTS: SPHLs tested 868 CRE isolates, 127 (14.6%) were from eight LCG. Overall, 195 (26.3%) EsKE isolates were CP-CRE, compared with 24 (18.9%) LCG isolates. LCG accounted for 24 (11.0%) of 219 CP-CRE identified.
CONCLUSIONS: Participating sites would have missed approximately 1 in 10 CP-CRE if isolate submission had been limited to EsKE genera. Expanding mechanism testing to additional genera could improve detection and prevention efforts.
Volume
3
Issue
3
First Page
137
Last Page
137
ISSN
2632-1823
Published In/Presented At
Shugart, A., Mahon, G., Huang, J. Y., Karlsson, M., Valley, A., Lasure, M., Gross, A., Pattee, B., Vaeth, E., Brooks, R., Maruca, T., Dominguez, C. E., Torpey, D., Francis, D., Bhattarai, R., Kainer, M. A., Chan, A., Dubendris, H., Greene, S. R., Blosser, S. J., … Spalding Walters, M. (2021). Carbapenemase production among less-common Enterobacterales genera: 10 US sites, 2018. JAC-antimicrobial resistance, 3(3), dlab137. https://doi.org/10.1093/jacamr/dlab137
Disciplines
Medicine and Health Sciences
PubMedID
34514407
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article