Mild Traumatic Brain Injury Is Related to Elevated Cerebrospinal Fluid Tau in Alzheimer's Disease Dementia.
Publication/Presentation Date
1-1-2022
Abstract
Few studies have examined an association between mild traumatic brain injury (mTBI) and Alzheimer's disease (AD). For this reason, we compared an AD dementia group with an mTBI history (n = 10) to a matched AD control group (n = 20) on measures of cognitive function, cerebral glucose metabolism, and markers of amyloid and tau deposition. Only a trend and medium-to-large effect size for higher phosphorylated and total tau was identified for the mTBI group. A history of mTBI may be associated with greater tau in AD, indicating a potential pathway for increasing risk for AD, though further evaluation with larger samples is needed.
Volume
87
Issue
4
First Page
1491
Last Page
1496
ISSN
1875-8908
Published In/Presented At
LoBue C, Kelley BJ, Hart J, Helphrey J, Schaffert J, Cullum CM, Peters ME, Douglas PM; Alzheimer’s Disease Neuroimaging Initiative. Mild Traumatic Brain Injury Is Related to Elevated Cerebrospinal Fluid Tau in Alzheimer's Disease Dementia. J Alzheimers Dis. 2022;87(4):1491-1496. doi: 10.3233/JAD-220112. PMID: 35491792; PMCID: PMC9241585.
Disciplines
Psychiatry
PubMedID
35491792
Department(s)
Department of Psychiatry
Document Type
Article