Memory decline in the aged: treatment with lecithin and physostigmine.
Publication/Presentation Date
9-1-1982
Abstract
Normal aged subjects were given lecithin and placebo for 5 weeks each in a double-blind crossover study. Supraspan tests of memory and learning failed to show any significant changes as a result of these treatments. Addition of a single IV infusion of physostigmine did not improve performance. These findings neither support nor weaken the "cholinergic hypothesis" of cognitive impairment in aging and dementia, but they imply that simple cholinergic hypofunction is unlikely.
Volume
32
Issue
9
First Page
944
Last Page
950
ISSN
0028-3878
Published In/Presented At
Drachman, D. A., Glosser, G., Fleming, P., & Longenecker, G. (1982). Memory decline in the aged: treatment with lecithin and physostigmine. Neurology, 32(9), 944–950. https://doi.org/10.1212/wnl.32.9.944
Disciplines
Medicine and Health Sciences | Psychiatry
PubMedID
6287359
Department(s)
Department of Psychiatry
Document Type
Article