Dynamic spectral-domain optical coherence elastography for tissue characterization.

Publication/Presentation Date

6-21-2010

Abstract

A dynamic spectral-domain optical coherence elastography (OCE) imaging technique is reported. In this technique, audio-frequency compressive vibrations are generated by a piezoelectric stack as external excitation, and strain rates in the sample are calculated and mapped quantitatively using phase-sensitive spectral-domain optical coherence tomography. At different driving frequencies, this technique provides contrast between sample regions with different mechanical properties, and thus is used to mechanically characterize tissue. We present images of a three-layer silicone tissue phantom and rat tumor tissue ex vivo, based on quantitative strain rate. Both acquisition speed and processing speed are improved dramatically compared with previous OCE imaging techniques. With high resolution, high acquisition speed, and the ability to characterize the mechanical properties of tissue, this OCE technique has potential use in non-destructive volumetric imaging and clinical applications.

Volume

18

Issue

13

First Page

14183

Last Page

14190

ISSN

1094-4087

Disciplines

Medicine and Health Sciences | Oncology

PubMedID

20588552

Department(s)

Department of Radiation Oncology

Document Type

Article

Link to Full Text

Share

COinS