Light chain cast nephropathy caused by plasmablastic lymphoma of the bladder

Document Type

Article

Publication Date

1-1-2021

Publication Title

Clinical nephrology. Case studies

E-ISSN

2196-5293

Department(s)

Department of Medicine; Hematology-Medical Oncology Division; Fellows and Residents

Keywords

HIV, acute kidney injury, bladder lymphoma, interstitial nephritis, light chain cast nephropathy, lymphoma, plasmablastic lymphoma

Abstract

INTRODUCTION: Plasmablastic lymphoma (PBL) is a rare form of B-cell lymphoma typically seen in patients with underlying immunosuppression such as HIV, autoimmune disease, and organ transplantation. PBL in HIV-positive patients usually originates from the gastrointestinal tract, with a predilection for the oral cavity. Bladder involvement by PBL is exceedingly rare, and cast nephropathy due to κ light chain-secreting PBL has not been reported previously. CASE REPORT: We report a patient who presented with acute kidney injury (AKI) in the setting of HIV, and was found to have a bladder tumor. Bladder pathology revealed a high-grade PBL with κ light chain restriction. Renal biopsy showed κ light chain cast nephropathy, presumably secondary to κ light chain-secreting PBL. CONCLUSION: Although the prognosis of PBL is poor, our patient recovered from AKI, achieved complete hematologic remission with chemotherapy, and underwent successful autologous stem cell transplant.

Volume

9

First Page

72

Last Page

80

DOI

10.5414/CNCS110339

PubMed ID

34235044

Link to Full Text

Share

COinS