Light chain cast nephropathy caused by plasmablastic lymphoma of the bladder
Document Type
Article
Publication Date
1-1-2021
Publication Title
Clinical nephrology. Case studies
E-ISSN
2196-5293
Department(s)
Department of Medicine; Hematology-Medical Oncology Division; Fellows and Residents
Keywords
HIV, acute kidney injury, bladder lymphoma, interstitial nephritis, light chain cast nephropathy, lymphoma, plasmablastic lymphoma
Abstract
INTRODUCTION: Plasmablastic lymphoma (PBL) is a rare form of B-cell lymphoma typically seen in patients with underlying immunosuppression such as HIV, autoimmune disease, and organ transplantation. PBL in HIV-positive patients usually originates from the gastrointestinal tract, with a predilection for the oral cavity. Bladder involvement by PBL is exceedingly rare, and cast nephropathy due to κ light chain-secreting PBL has not been reported previously. CASE REPORT: We report a patient who presented with acute kidney injury (AKI) in the setting of HIV, and was found to have a bladder tumor. Bladder pathology revealed a high-grade PBL with κ light chain restriction. Renal biopsy showed κ light chain cast nephropathy, presumably secondary to κ light chain-secreting PBL. CONCLUSION: Although the prognosis of PBL is poor, our patient recovered from AKI, achieved complete hematologic remission with chemotherapy, and underwent successful autologous stem cell transplant.
Volume
9
First Page
72
Last Page
80
DOI
10.5414/CNCS110339
PubMed ID
34235044
Recommended Citation
Jafarizade, M., Goli, K. M., D'Agati, V., Dulaimi, E., Daniel, K., Lash, B., & Maynard, S. E. (2021). Light chain cast nephropathy caused by plasmablastic lymphoma of the bladder. LVHN Scholarly Works. Retrieved from https://scholarlyworks.lvhn.org/research-historical-works/53
DOI: 10.5414/CNCS110339
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