The Role of Interleukin-27 in Atherosclerosis: A Contemporary Review

Authors

Mehrian Jafarizade, Lehigh Valley Health Network
Farima Kahe, Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Sadaf Sharfaei, Baim Institute for Clinical Research, Boston, Massachusetts, USA.
Kaveh Momenzadeh, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Anmol Pitliya, West Virginia University College of Medicine/Camden Clark Medical Center, Parkersburg, West Virginia, USA.
Farbod Zahedi Tajrishi, Tehran Heart Center, Tehran, Iran.
Preeti Singh, Mass General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Gerald Chi, Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Document Type

Article

Publication Date

1-1-2021

Publication Title

Cardiology

E-ISSN

1421-9751

Department(s)

Department of Medicine; Fellows and Residents

Keywords

Atherosclerosis, Interleukin-27, NLRP3 inflammasome, Reperfusion injury

Abstract

Atherosclerosis is a chronic inflammation characterized by an imbalance between inhibitors and stimulators of the inflammatory system that leads to the formation of atherosclerotic plaques in the vessel walls. Interleukin (IL)-27 is one of the recently discovered cytokines that have an immunomodulatory role in autoimmune and inflammatory diseases. However, the definite role of IL-27 in the pathogenesis of atherosclerosis remains unclear. Recent studies on cardiomyocytes and vascular endothelium have demonstrated mechanisms through which IL-27 could potentially modulate atherosclerosis. Upregulation of the IL-27 receptor was also observed in the atherosclerotic plaques. In addition, circulatory IL-27 levels were increased in patients with acute coronary syndrome and myocardial infarction. A regenerative, neovascularization, and cardioprotective role of IL-27 has also been implicated. Future studies are warranted to elucidate the biologic function and clinical significance of IL-27 in atherosclerosis.

Volume

146

Issue

4

First Page

517

Last Page

530

DOI

10.1159/000515359

PubMed ID

34010834

Recommended Citation

Jafarizade, M., Kahe, F., Sharfaei, S., Momenzadeh, K., Pitliya, A., Zahedi Tajrishi, F., Singh, P., & Chi, G. (2021). The Role of Interleukin-27 in Atherosclerosis: A Contemporary Review. LVHN Scholarly Works. Retrieved from https://scholarlyworks.lvhn.org/research-historical-works/92
DOI: 10.1159/000515359