Department of Medicine; Fellows and Residents
Atherosclerosis, Interleukin-27, NLRP3 inflammasome, Reperfusion injury
Atherosclerosis is a chronic inflammation characterized by an imbalance between inhibitors and stimulators of the inflammatory system that leads to the formation of atherosclerotic plaques in the vessel walls. Interleukin (IL)-27 is one of the recently discovered cytokines that have an immunomodulatory role in autoimmune and inflammatory diseases. However, the definite role of IL-27 in the pathogenesis of atherosclerosis remains unclear. Recent studies on cardiomyocytes and vascular endothelium have demonstrated mechanisms through which IL-27 could potentially modulate atherosclerosis. Upregulation of the IL-27 receptor was also observed in the atherosclerotic plaques. In addition, circulatory IL-27 levels were increased in patients with acute coronary syndrome and myocardial infarction. A regenerative, neovascularization, and cardioprotective role of IL-27 has also been implicated. Future studies are warranted to elucidate the biologic function and clinical significance of IL-27 in atherosclerosis.
Jafarizade, M., Kahe, F., Sharfaei, S., Momenzadeh, K., Pitliya, A., Zahedi Tajrishi, F., Singh, P., & Chi, G. (2021). The Role of Interleukin-27 in Atherosclerosis: A Contemporary Review. LVHN Scholarly Works. Retrieved from https://scholarlyworks.lvhn.org/research-historical-works/92