Document Type

Article

Publication Date

1-1-2021

Publication Title

Cardiology

E-ISSN

1421-9751

Department(s)

Department of Medicine; Fellows and Residents

Keywords

Atherosclerosis, Interleukin-27, NLRP3 inflammasome, Reperfusion injury

Abstract

Atherosclerosis is a chronic inflammation characterized by an imbalance between inhibitors and stimulators of the inflammatory system that leads to the formation of atherosclerotic plaques in the vessel walls. Interleukin (IL)-27 is one of the recently discovered cytokines that have an immunomodulatory role in autoimmune and inflammatory diseases. However, the definite role of IL-27 in the pathogenesis of atherosclerosis remains unclear. Recent studies on cardiomyocytes and vascular endothelium have demonstrated mechanisms through which IL-27 could potentially modulate atherosclerosis. Upregulation of the IL-27 receptor was also observed in the atherosclerotic plaques. In addition, circulatory IL-27 levels were increased in patients with acute coronary syndrome and myocardial infarction. A regenerative, neovascularization, and cardioprotective role of IL-27 has also been implicated. Future studies are warranted to elucidate the biologic function and clinical significance of IL-27 in atherosclerosis.

Volume

146

Issue

4

First Page

517

Last Page

530

DOI

10.1159/000515359

PubMed ID

34010834

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