USF-LVHN SELECT
The Association between Polluted Neighborhoods and
Publication/Presentation Date
8-1-2021
Abstract
BACKGROUND: Poor patients often reside in neighborhoods of lower socioeconomic status (SES) with high levels of airborne pollutants. They also have higher mortality from non-small cell lung cancer (NSCLC) than those living in wealthier communities. We investigated whether living in polluted neighborhoods is associated with somatic mutations linked with lower survival rates, i.e.,
METHODS: In a retrospective cohort of 478 patients with NSCLC treated at a comprehensive cancer center between 2015 and 2018, we used logistic regression to assess associations between individual demographic and clinical characteristics, including somatic
RESULTS: 277 patients (58%) had somatic
CONCLUSIONS: When controlling for individual- and neighborhood-level confounders, we find that the odds of having a
IMPACT: The link between pollution and aggressive biology may contribute to the increased burden of adverse NSCLC outcomes in individuals living in lower SES neighborhoods.
Volume
30
Issue
8
First Page
1498
Last Page
1505
ISSN
1538-7755
Published In/Presented At
Erhunmwunsee, L., Wing, S. E., Shen, J., Hu, H., Sosa, E., Lopez, L. N., Raquel, C., Sur, M., Ibarra-Noriega, P., Currey, M., Lee, J., Kim, J. Y., Raz, D. J., Amini, A., Sampath, S., Koczywas, M., Massarelli, E., West, H. L., Reckamp, K. L., Kittles, R. A., … Gray, S. W. (2021). The Association between Polluted Neighborhoods and TP53-Mutated Non-Small Cell Lung Cancer. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 30(8), 1498–1505. https://doi.org/10.1158/1055-9965.EPI-20-1555
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
34088750
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article